Running may be the single most effective exercise to increase life expectancy, according to a new review and analysis of past research about exercise and premature death. The new study found that, compared to nonrunners, runners tended to live about three additional years, even if they run slowly or sporadically and smoke, drink or are overweight. No other form of exercise that researchers looked at showed comparable impacts on life span.

The findings come as a follow-up to a study done three years ago, in which a group of distinguished exercise scientists scrutinized data from a large trove of medical and fitness tests conducted at the Cooper Institute in Dallas. That analysis found that as little as five minutes of daily running was associated with prolonged life spans.

After that study was released, the researchers were inundated with queries from fellow scientists and the general public, says Duck-chul Lee, a professor of kinesiology at Iowa State University and a co-author of the study. Some people asked if other activities, such as walking, were likely to be as beneficial as running for reducing mortality risks.

High-mileage runners wondered if they could be doing too much, and if at some undefined number of miles or hours, running might become counterproductive and even contribute to premature mortality.

And a few people questioned whether running really added materially to people’s life spans. Could it be, they asked rather peevishly, that if in order to reduce your risk of dying by a year, you had to spend the equivalent of a year’s worth of time on the trails or track, producing no discernible net gain?

So for the new study, which was published last month in Progress in Cardiovascular Disease, Dr. Lee and his colleagues set out to address those and related issues by reanalyzing data from the Cooper Institute and also examining results from a number of other large-scale recent studies looking into the associations between exercise and mortality.

Over all, this new review reinforced the findings of the earlier research, the scientists determined. Cumulatively, the data indicated that running, whatever someone’s pace or mileage, dropped a person’s risk of premature death by almost 40 percent, a benefit that held true even when the researchers controlled for smoking, drinking and a history of health problems such as hypertension or obesity.

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Jeffrey R. Ungvary President